Use of Budesonide/Surfactant to Prevent Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is one of the most common complications in premature infants and is characterized by lung injury that affects alveolar and pulmonary vascular development. Yeh et al sought to compare intra-tracheal administration of surfactant/budesonide with that of surfactant alone on the incidence of death or BPD in very-low-birth-weight infants with severe respiratory distress syndrome.

They found that in very-low-birth-weight infants with severe respiratory distress syndrome, intra-tracheal administration of surfactant/budesonide compared with surfactant alone significantly decreased the incidence of BPD without immediate adverse effect.

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