Sedatives and Their Associations with VAEs and Time to Extubation

Sedative selection is crucial to outcomes in critically ill patients. While benzodiazepines are known to be associated with a longer duration of mechanical ventilation compared to propofol and dexmedetomidine, little data exist comparing these sedatives in association with ventilator-associated events (VAEs). Klompas et al therefore aimed to evaluate the association between these sedatives, VAEs and time to extubation.

They found that sedatives vary in their associations with VAEs and time to extubation but not in their associations with time to hospital discharge or mortality.

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