Traumatic brain injury (TBI) is a leading cause of death and disability in children. Early posttraumatic seizures can exacerbate some of the metabolic and physiologic derangements seen with TBI. In a prospective observational study by Chung and O’Brien, the authors sought to evaluate the prevalence of early seizures after levetiracetam prophylaxis in children with moderate to severe TBI.
They found that early clinical posttraumatic seizures occurred frequently in children with moderate to severe TBI despite seizure prophylaxis with levetiracetam.
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