Predicting Mortality in Patients with Sepsis

Sepsis is an important cause of mortality in critical care, yet it is a heterogeneous syndrome in which patients with otherwise similar presenting clinical characteristics may rapidly progress to death or improve with minimal intervention. Therefore, Mikacenic et al (Am J Respir Crit Care Med. 2017;196:1004-1011) set out to assess the utility of a multibiomarker-based model to predict 28-day mortality among critically ill patients with at least two systemic inflammatory response syndrome criteria and/or sepsis.

Their findings offer insight into diagnostics to better prognosticate and ultimately direct specific therapies to achieve optimal clinical outcomes in heterogeneous groups of critically ill patients.

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