Sepsis is an important cause of mortality in critical care, yet it is a heterogeneous syndrome in which patients with otherwise similar presenting clinical characteristics may rapidly progress to death or improve with minimal intervention. Therefore, Mikacenic et al (Am J Respir Crit Care Med. 2017;196:1004-1011) set out to assess the utility of a multibiomarker-based model to predict 28-day mortality among critically ill patients with at least two systemic inflammatory response syndrome criteria and/or sepsis.
Their findings offer insight into diagnostics to better prognosticate and ultimately direct specific therapies to achieve optimal clinical outcomes in heterogeneous groups of critically ill patients.
Read the full Concise Critical Appraisal by logging in to the SCCM eCommunity. Concise Critical Appraisal is a regular feature aimed at highlighting the best and most relevant literature from a variety of academic journals and encouraging discussion around recent studies and research.