Is Fluid Overload Associated with Mortality in Children?

Early fluid resuscitation remains an integral therapy in most critically ill children with sepsis.  However, as of late, an increasing body of literature (i.e., studies by Modem et al and Sutherland et al) has reported that fluid overload in critical illness may be associated with increasing mortality. Sinitsky and colleagues investigated the association of early fluid overload with respiratory parameters and mortality in a general pediatric intensive care unit (PICU) population.

The authors found that, in this general PICU population, fluid overload percent (%FO) at 48 hours was associated with oxygenation index at 48 hours and need for invasive ventilation in survivors. However, no association was detected between %FO and mortality.

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