Examining Pantoprazole or Placebo for Stress Ulcer Prophylaxis

Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. However, comparison to placebo has been inadequately evaluated, and pantoprazole has the potential to cause harm. Therefore, Selvanderan and colleagues set out to evaluate benefit or harm associated with pantoprazole administration.

They found no evidence of benefit or harm with the prophylactic administration of pantoprazole to mechanically ventilated critically ill patients anticipated to receive enteral nutrition.

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