Effect of RBC Transfusion on Cerebral Autoregulation in Severe TBI Patients

What is the impact of red blood cell (RBC) transfusion on cerebral autoregulation in patients with severe traumatic brain injury (TBI)? Seeking to find out, Sekhon et al conducted a retrospective, single-center, cohort study to evaluate the relationship between RBC transfusion and cerebral autoregulation as measured by pressure reactivity index (PRx).

They found that RBC transfusion in severe TBI patients results in worsening PRx, indicating impaired cerebral autoregulation.

Read the full Concise Critical Appraisal by logging into the SCCM eCommunity. Concise Critical Appraisal is a regular feature aimed at highlighting the best and most relevant literature from a variety of academic journals and encouraging discussion around recent studies and research.

eNewsletter Issue: