What is the impact of red blood cell (RBC) transfusion on cerebral autoregulation in patients with severe traumatic brain injury (TBI)? Seeking to find out, Sekhon et al conducted a retrospective, single-center, cohort study to evaluate the relationship between RBC transfusion and cerebral autoregulation as measured by pressure reactivity index (PRx).
They found that RBC transfusion in severe TBI patients results in worsening PRx, indicating impaired cerebral autoregulation.
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