There have been many international consensus statements on the diagnosis and management of pediatric sepsis and septic shock during the past few decades. However, because of the complexity and variability in the presentation and natural course of the disease, specific recommendations regarding the ideal vasoactive agent remain controversial. Ventura et al used clinical and laboratory parameters to determine whether children with fluid-refractory septic shock would benefit more from a potent inotrope (i.e., epinephrine) than from dopamine.
Overall, the study suggested a significant benefit to using epinephrine as a first-line agent (compared to dopamine).
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