Despite years of research, sepsis remains a significant cause of mortality worldwide. The host response to sepsis is varied, and the patient response to directed therapies is heterogeneous, making it difficult to identify those at risk for poor outcomes using clinical features. Therefore, Scicluna et al (Lancet Respir Med. 2017;5:816-826) set out to identify biologically relevant molecular endotypes in patients with sepsis.
Their study methods and findings outline some early steps in the implementation of precision medicine in sepsis.
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