Sepsis remains a major cause of mortality in the intensive care unit. Numerous studies have attempted to elucidate the exact pathophysiology of sepsis at the cellular level, including identifying specific proteins in common pathways associated with survival. Although prior studies have had promising but limited success, the recent development and utilization of advanced genomic and proteomic databases have yielded intriguing findings that may link particular proteins and mechanisms to sepsis mortality. DeCoux et al used glycoprotein analysis to determine whether changes in plasma glycoproteins may predict mortality in severe sepsis.
This study ultimately identified proteins linked to patient outcomes and provided insight into unexplored mechanisms that can be investigated for the identification of novel therapeutic targets.
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