Antibiotic Timing and Mortality in Sepsis

The current standard of care for sepsis is the early administration of antibiotics. However, efforts to shorten time to antibiotic administration may also cause harm because more patients may receive unnecessary antibiotics. Liu et al  evaluated the association between antibiotic timing and mortality among patients with sepsis receiving antibiotics within 6 hours of emergency department registration.

They found that hourly delays in antibiotic administration for patients with sepsis were associated with increased odds of hospital mortality, even among patients who received antibiotics within 6 hours.

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